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KMID : 0043320090320030353
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Archives of Pharmacal Research
2009 Volume.32 No. 3 p.353 ~ p.358
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Beneficial Effects of the Combination of Amlodipine and Losartan for Lowering Blood Pressure in Spontaneously Hypertensive Rats
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Yoo Moo-Hi
Ahn Byoung-Ok
Kim Jeong-Hoon
Kang Kyung-Koo
Seo Mi-Jung
Choi Seul-Min
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Abstract
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A combination of antihypertensive agents can better control blood pressure and reduce the number and severity of side effects than a monotherapy. Since both CCBs (calcium channel blockers) and ARBs (angiotensin II receptor type-1 blockers) are current and effective antihypertensive drugs, this study assessed the synergistic antihypertensive effects as well as the optimal combination ratio of these two drugs. Amlodipine (3 mg/kg) or losartan (30 mg/kg) alone or a combination of each drug at a ratio 1:10 and 1:20 was administered orally to spontaneously hypertensive rats (SHR). A four-week treatment of either 3 mg/kg amlodipine or 30 mg/kg losartan alone decreased the systolic blood pressure (SBP). However, their combination significantly lowered the SBP from the 3rd week, and there was a positive correlation between this reduction in blood pressure and the improvement in arterial endothelium-dependent relaxation. In addition, the combination therapy (1:20) decreased both the cardiac mass and left ventricular weight to a greater extent than with either amlodipine or losartan alone. The collagen content in the cardiac tissue was also significantly lower after the 4-week combination therapy (1:10). These results suggest that the combined use of amlodipine and losartan might be more effective in treating hypertension than a monotherapy.
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KEYWORD
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Amlodipine, Losartan, Combination, Spontaneously hypertensive rat, Systolic blood pressure
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